HT is a 31 year old female with acute, uncomplicated cystitis and no known drug allergies.  She has no significant PMH or medications. 

Often infections have several treatment possibilities, depending on both patient specific and disease specific characteristics.  Below is a very short case, and I want you as a class to compare and contrast the listed treatment options.  The focus will be on safety and efficacy of the regimens, all considered possible choices by the Infectious Disease Society of America’s treatment guidelines for Acute Uncomplicated Cystitis.

HT is a 31 year old female with acute, uncomplicated cystitis and no known drug allergies.  She has no significant PMH or medications.  Her urine culture shows a susceptible E. coli (susceptible to all treatments listed below).  Please compare the safety and efficacy of the following options.  What would make you choose one over another?

  1. nitrofurantoin 100 mg po BID x 7 days
  2. TMP/SMX DS (160 mg/800 mg) po BID x 3 days
  3. levofloxacin 250 mg po daily x 3 days
  4. cephalexin 500 mg po q12hrs x 7-14 days

Responses should be a minimum of 150 words, scholarly written, 7th Ed APA formatted, and referenced.  A minimum of 2 Journal article references are required.

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